BDBM19905 (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-{3-[4-(methylsulfanyl)phenyl]-2-oxo-1,2-dihydropyridin-4-yl}cyclohexane-1-carboxamide::beta-substituted cyclohexanecarboxamide, 6

SMILES CSc1ccc(cc1)-c1c(cc[nH]c1=O)[C@@H]1CCC(F)(F)C[C@H]1C(=O)NCC#N

InChI Key InChIKey=PRMPFYDBURPTBI-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19905   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19905((1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-{3-[4-(meth...)
Affinity DataIC50: 6nM EC50:  84nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19905((1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-{3-[4-(meth...)
Affinity DataIC50: 8nM EC50:  84nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed