BDBM19907 (1R,2R)-2-{1-benzyl-5-[4-(methylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl}-N-(cyanomethyl)-5,5-difluorocyclohexane-1-carboxamide::beta-substituted cyclohexanecarboxamide, 8

SMILES CSc1ccc(cc1)-c1c(nnn1Cc1ccccc1)[C@@H]1CCC(F)(F)C[C@H]1C(=O)NCC#N

InChI Key InChIKey=VSXIBNPUZDZFBP-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19907   

TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19907((1R,2R)-2-{1-benzyl-5-[4-(methylsulfanyl)phenyl]-1...)
Affinity DataIC50: 2nM EC50:  33nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed
TargetCathepsin K(Rabbit)
Merck Frosst Centre For Therapeutic Research

LigandPNGBDBM19907((1R,2R)-2-{1-benzyl-5-[4-(methylsulfanyl)phenyl]-1...)
Affinity DataIC50: 9nM EC50:  33nMpH: 5.5 T: 2°CAssay Description:Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2008
Entry Details Article
PubMed