BDBM199201 6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroacridin-9-amine (12c)

SMILES Clc1ccc2c(NCc3ccccn3)c3CCCCc3nc2c1

InChI Key InChIKey=FKNJQDQMEVFNQX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 199201   

TargetAcetylcholinesterase(Human)
University of Waterloo

LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 90nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Waterloo

LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in insect cells using EOMCC as substrate pretreated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 1.60E+3nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM199201(6-Chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in insect cells using DBOMF as substrate pretreated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed