BDBM199292 US9221808, 1at

SMILES OC[C@@H](NC(=O)Nc1nc(cs1)-c1ccncc1)c1ccccc1

InChI Key InChIKey=OQORIVHBMBWOAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 199292   

TargetRho-associated protein kinase 2(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199292(US9221808, 1at)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199292(US9221808, 1at)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199292(US9221808, 1at)
Affinity DataIC50: 30nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM199292(US9221808, 1at)
Affinity DataIC50: 30nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent