BDBM199367 US9221831, 32
SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1CS(=O)Cc1ccccc1)OC
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 199367
Affinity DataKi: 0.430nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
Affinity DataEC50: 9.08nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. kippa opioid receptor membrane solution was prepared by sequentially adding final...More data for this Ligand-Target Pair
Affinity DataKi: 14.0nM ΔG°: -11.6kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand dose-displacement binding assays for t-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane...More data for this Ligand-Target Pair
Affinity DataEC50: 50.4nMpH: 7.4 T: 2°CAssay Description:[35S]GTPgammaS functional assays were conducted using freshly thawed u-receptor membranes (Perkin Elmer, Shelton, Conn.). Assay reactions were prepar...More data for this Ligand-Target Pair
Affinity DataEC50: 231nMpH: 7.4 T: 2°CAssay Description:Functional [35S]GTPgammaS binding assays were conducted as follows. Delta opioid receptor membrane solution was prepared by sequentially adding final...More data for this Ligand-Target Pair
Affinity DataKi: 381nM ΔG°: -8.75kcal/molepH: 7.4 T: 2°CAssay Description:Delta-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin E...More data for this Ligand-Target Pair
Affinity DataKi: 6.02E+3nM ΔG°: -7.71kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...More data for this Ligand-Target Pair