BDBM200531 Roche-Dataset for PDE10A, Compound 368::US9227970, 28

SMILES CCN(CC)c1nc2ccc(NC(=O)c3c(cnn3C)C(=O)N3CCC3)cn2n1

InChI Key InChIKey=GYBBIJWODKWJIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 200531   

LigandPNGBDBM200531(US9227970, 28 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 3.28nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM200531(US9227970, 28 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 3.30nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
US Patent