BDBM200637 US9227977, Compound (Ia)

SMILES Nc1ncnc2n(Cc3nc4cccc(C#CCOCCOCCO)c4c(=O)n3Cc3ccccc3C(F)(F)F)nc(-c3cc(O)cc(F)c3)c12

InChI Key InChIKey=DNKXAAPJUKKDSI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200637   

LigandPNGBDBM200637(US9227977, Compound (Ia))
Affinity DataIC50:  17nMAssay Description:As a means of assessing PI3K δ activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product of PI3K&#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200637(US9227977, Compound (Ia))
Affinity DataIC50: >1.42E+4nMAssay Description:As a means of assessing PI3K alpha or beta; activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200637(US9227977, Compound (Ia))
Affinity DataIC50: >1.42E+4nMAssay Description:As a means of assessing PI3K alpha or beta; activation in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200637(US9227977, Compound (Ia))
Affinity DataIC50:  577nMAssay Description:As a means of assessing the activation of PI3K γ in response to stimuli, the phosphorylation status of the protein, Akt, a downstream product of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent