BDBM201625 (e)-4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)vinyl)quinazolin-4-yl)morpholine::Roche-Dataset for PDE10A, Compound 235::US9540384, 19

SMILES Clc1ccc2nc(\C=C\c3cccc(n3)N3CCCC3)nc(N3CCOCC3)c2c1

InChI Key InChIKey=WGYAAGRVGZZKOO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 201625   

LigandPNGBDBM201625((e)-4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Affinity DataIC50: 6.30nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

LigandPNGBDBM201625((e)-4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Affinity DataIC50: 6.31nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed