BDBM202251 5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl)ethyl)-[1,2,4]triazolo-[1,5-a]pyrimidine::Roche-Dataset for PDE10A, Compound 998::US9540384, 46

SMILES Cc1cc(C)n2nc(CCc3cncc(n3)N3CCCC3)nc2n1

InChI Key InChIKey=RLPWDIXGEDQNHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 202251   

LigandPNGBDBM202251(5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Affinity DataIC50: 300nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent

LigandPNGBDBM202251(5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Affinity DataIC50: 307nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed