BDBM202291 2-hydroxy-1-((3ar,5s,6as)-5-(methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1h)-yl)ethanone::US9527851, example 6

SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OO)c1ncnc2[nH]ccc12

InChI Key InChIKey=ZOKBKKLNNUVULU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202291   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202291(US9527851, example 6 | 2-hydroxy-1-((3ar,5s,6as)-5...)
Affinity DataIC50: 5nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202291(US9527851, example 6 | 2-hydroxy-1-((3ar,5s,6as)-5...)
Affinity DataIC50: 11nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202291(US9527851, example 6 | 2-hydroxy-1-((3ar,5s,6as)-5...)
Affinity DataIC50: 45nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent