BDBM202309 2-hydroxy-1-((3ar,5r,6as)-5-(methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino) hexahydrocyclopenta[c]pyrrol-2(1h)-yl)ethanone::US9527851, example 23

SMILES CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12

InChI Key InChIKey=NZHSLDWIEHMESB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 202309   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202309(US9527851, example 23 | 2-hydroxy-1-((3ar,5r,6as)-...)
Affinity DataIC50: 21nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
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Date in BDB:
8/16/2018
Entry Details
US Patent