BDBM202321 (4as,7ar)-methyl 6-(methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino) hexahydro-1h-cyclopenta[c]pyridine-2(3h)-carboxylate::US9527851, example 36

SMILES COC(=O)N1CC[C@H]2C[C@@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12

InChI Key InChIKey=QCBFFVVAONXLHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 202321   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202321(US9527851, example 36 | (4as,7ar)-methyl 6-(methyl...)
Affinity DataIC50: 25nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM202321(US9527851, example 36 | (4as,7ar)-methyl 6-(methyl...)
Affinity DataIC50: 75nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent