BDBM20288 2-[(4-tert-butylphenyl)methyl]-3-[1-(3-fluoro-4-methanesulfonamidophenyl)acetamido]propyl 2,2-dimethylpropanoate::CHEMBL72104::amide analogue, 3

SMILES CC(C)(C)C(=O)OCC(CNC(=O)Cc1ccc(NS(C)(=O)=O)c(F)c1)Cc1ccc(cc1)C(C)(C)C

InChI Key InChIKey=RERDOWROKULWDB-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20288   

TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20288(CHEMBL72104 | 2-[(4-tert-butylphenyl)methyl]-3-[1-...)
Affinity DataKi:  74nMAssay Description:Agonist effect on 45 [Ca2+] influx in vanilloid receptor expressing CHO cells relative to maximal capsaicin (300 nM) responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20288(CHEMBL72104 | 2-[(4-tert-butylphenyl)methyl]-3-[1-...)
Affinity DataKi:  74nM ΔG°:  -10.1kcal/mole EC50:  440nMpH: 7.4 T: 2°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20288(CHEMBL72104 | 2-[(4-tert-butylphenyl)methyl]-3-[1-...)
Affinity DataIC50: 440nMAssay Description:In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid receptor expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed