BDBM20293 2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-methanesulfonamidophenyl)methyl]carbamothioyl}amino)propyl 2,2-dimethylpropanoate::CHEMBL254245::thiourea antagonist, 2b

SMILES Cc1ccc(CC(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)COC(=O)C(C)(C)C)cc1C

InChI Key InChIKey=MBFLALIYFBMPJK-UHFFFAOYSA-N

Data  6 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 20293   

TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  7.80nMAssay Description:Inhibition of capsaicin-induced [Ca2+] uptake by Rat Vanilloid receptor 1 (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  54nM ΔG°:  -10.3kcal/mole EC50:  7.80nMpH: 7.4 T: 2°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  7.80nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of 45Ca2+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataIC50: 7.80nMAssay Description:In vitro antagonist effect against 50 nM capsaicin-induced 45 [Ca2+] influx in vanilloid receptor expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  54nMAssay Description:In vitro binding affinity towards Rat Vanilloid receptor 1 (VR1) by [3H]RTX displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  54nMAssay Description:Binding affinity towards rat vanilloid receptor subtype 1 expressed in CHO cells by [3H]RTX displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20293(CHEMBL254245 | 2-[(3,4-dimethylphenyl)methyl]-3-({...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]RTX from rat TRPV1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed