BDBM203320 (6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-pyrimidin-4-yl-5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocine::US10053462, 197::US9540388, 197

SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccncn4)n2C3)c1Cl

InChI Key

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 203320   

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  63nM IC50: 1.70nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  19nM IC50: 1.70nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataIC50: 10.7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  63nM IC50: 11nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  19.1nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  63nM IC50: 1.49E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataKi:  63.1nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM203320(US10053462, 197 | US9540388, 197 | (6r,10s)-11-{[2...)
Affinity DataIC50: 1.49E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent