BDBM204725 1-[2-chloro-5-(4,4,4,-trifluoro-butoxy)-phenyl]-4,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline::US9540379, 110

SMILES Cc1ccc2nc(C)c3nnc(-c4cc(OCCCC(F)(F)F)ccc4Cl)n3c2c1

InChI Key InChIKey=ISJMXGJOHQASQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 204725   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204725(US9540379, 110 | 1-[2-chloro-5-(4,4,4,-trifluoro-b...)
Affinity DataIC50: 4nMAssay Description:The DNA encoding PDE2A (NM002599) was cloned and the gene was inserted in the baculovirus and the enzyme-protein expressed in SF21-cells. The enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM204725(US9540379, 110 | 1-[2-chloro-5-(4,4,4,-trifluoro-b...)
Affinity DataIC50: 1.00E+3nMAssay Description:The DNA of PDE10A1 (AB 020593, 2340 bp) was synthesized and cloned into the vector pCR4. TOPO (Entelechon GmbH, Regensburg, Germany). The gene was th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2018
Entry Details
US Patent