BDBM206140 US9255110, 53

SMILES COc1ccc(Cl)cc1NC(=O)c1csc2cnc(NCCN)nc12

InChI Key InChIKey=UIEHXCCYHAUOFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 206140   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Roche Palo Alto

US Patent
LigandChemical structure of BindingDB Monomer ID 206140BDBM206140(US9255110, 53)
Affinity DataIC50: 107nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Roche Palo Alto

US Patent
LigandChemical structure of BindingDB Monomer ID 206140BDBM206140(US9255110, 53)
Affinity DataIC50: 350nMpH: 7.2 T: 2°CAssay Description:SYK activity is measured by phosphorylation of a peptide substrate (Biotin-EPEGDYEEVLE) with [gamma-33P] ATP. The enzyme reaction was conducted at 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Roche Palo Alto

US Patent
LigandChemical structure of BindingDB Monomer ID 206140BDBM206140(US9255110, 53)
Affinity DataIC50: 813nMAssay Description:Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
US Patent