BDBM207568 US10501467, Example 13::US9260440, 13::US9617273, Example 13

SMILES CN(C)c1ccc(C2CC3=NNC(=O)c4cccc5[nH]c(c3c45)C2)cc1

InChI Key InChIKey=NAIANWLEXAZZRE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 207568   

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207568BDBM207568(US9260440, 13 | US9617273, Example 13 | US10501467...)
Affinity DataIC50: 19.8nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207568BDBM207568(US9260440, 13 | US9617273, Example 13 | US10501467...)
Affinity DataIC50: 20nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207568BDBM207568(US9260440, 13 | US9617273, Example 13 | US10501467...)
Affinity DataIC50: 1.98E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent