BDBM207590 US10501467, Example 35::US9260440, 35::US9617273, Example 35

SMILES O=C1NN=C2CCCc3c2c2c1cccc2n3CCN1CCCCC1

InChI Key InChIKey=KVSHPARHGQSONL-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 207590   

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 10nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 10nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataEC50:  23nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 130nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 130nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 1.00E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 207590BDBM207590(US9260440, 35 | US9617273, Example 35 | US10501467...)
Affinity DataIC50: 1.30E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent