BDBM20783 CHEMBL212133::Pyridothiazole analogue, 27::diethyl {2-[6-amino-8-({7-bromopyrido[3,4-d][1,3]thiazol-2-yl}sulfanyl)-9H-purin-9-yl]ethyl}phosphonate

SMILES CCOP(=O)(CCn1c(Sc2nc3cncc(Br)c3s2)nc2c(N)ncnc12)OCC

InChI Key InChIKey=SECQDSIPIFHPOE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20783   

TargetHeat shock protein HSP 90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM20783(CHEMBL212133 | diethyl {2-[6-amino-8-({7-bromopyri...)
Affinity DataIC50: 28nMAssay Description:Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM20783(CHEMBL212133 | diethyl {2-[6-amino-8-({7-bromopyri...)
Affinity DataEC50:  28nMAssay Description:EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2008
Entry Details Article
PubMed