BDBM208004 (r)-8-(2-chloro-5- ethylphenyl)-6-((1- cyclobutylethyl)amino)- 7-(4-(trifluoromethyl) benzyl)-7h-purine-2- carboxylic acid::US9540377, 1.2

SMILES CCc1ccc(Cl)c(c1)-c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=HVZVCDQUQRBYFF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 208004   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 208004BDBM208004(US9540377, 1.2 | (r)-8-(2-chloro-5- ethylphenyl)-6...)
Affinity DataIC50: 23.8nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent