BDBM208547 US9266876, 14

SMILES O=C(Cn1cnc2cccnc12)N1CCN(CC1)c1scnc1-c1nc2ccccc2[nH]1

InChI Key InChIKey=SCZVUUKBPVPDQO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 208547   

LigandChemical structure of BindingDB Monomer ID 208547BDBM208547(US9266876, 14)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2017
Entry Details
US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 208547BDBM208547(US9266876, 14)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at recombinant human CXCR3 expressed in human CHO-K1 cells co-expressing Galpha15 incubated for 10 mins by Fluo-4AM dye based FLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 208547BDBM208547(US9266876, 14)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of CXCR3 receptor internalization in human venous whole blood incubated for 30 mins by flow cytometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed