BDBM210186 7-(4-chloro-3- fluorobenzyl)-6-{[(1r)- 1- cyclobutylethyl]amino}- 8-[4-(propan-2- yl)pyridin-2-yl]-7h- purine-2-carboxylic acid::US9540377, 1.6

SMILES CC(C)c1ccnc(c1)-c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(Cl)c(F)c1)C(O)=O

InChI Key InChIKey=YBHIMQSTSIMNJP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 210186   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 210186BDBM210186(US9540377, 1.6 | 7-(4-chloro-3- fluorobenzyl)-6-{[...)
Affinity DataIC50: 2.79nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent