BDBM210187 6-{[(1r)-1- cyclobutylethyl]amino}- 8-[4-(propan-2- yl)pyridin-2-yl]-7-{[5- (trifluoromethyl)thiophen- 2-yl]methyl}-7h-purine- 2-carboxylic acid::US9540377, 1.7

SMILES CC(C)c1ccnc(c1)-c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(s1)C(F)(F)F)C(O)=O

InChI Key InChIKey=QQFUNIRANSHQLC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 210187   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 210187BDBM210187(US9540377, 1.7 | 6-{[(1r)-1- cyclobutylethyl]amino...)
Affinity DataIC50: 26.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent