BDBM2130 1-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-3-[5-(trifluoromethyl)-1,3-thiazol-2-yl]thiourea::LY300046HCl Analog 15::N-[2-(2-Chloro-3-ethoxy-6-fluorophenethyl)]-N-[2-(5-(trifluoromethyl)thiazolyl)]thiourea::PETT deriv.

SMILES CCOc1ccc(F)c(CCNC(=S)Nc2ncc(s2)C(F)(F)F)c1Cl

InChI Key InChIKey=MFJMKWIDCDUHBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2130   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2130(1-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-3-[5...)
Affinity DataIC50: 47nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2130(1-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-3-[5...)
Affinity DataIC50: 7.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2130(1-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]-3-[5...)
Affinity DataIC50: 7.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2004
Entry Details Article
PubMed