BDBM213028 US9278960, 4-112::US9278960, 4-113::US9278960, 4-114::US9278960, 4-115::US9663506, Example 4-115

SMILES CC1CN(Cc2ccc3c(cc(nc3c2)C(N)=O)-c2ccc(F)cc2)CC(N1)C(F)(F)F

InChI Key InChIKey=FIVYBYGNDSMHNJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 213028   

LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 23nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 23nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 23nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 24nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 24nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 24nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 34nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 34nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2017
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213028BDBM213028(US9278960, 4-114 | US9278960, 4-115 | US9278960, 4...)
Affinity DataIC50: 34nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent