BDBM213841 6-{[(1r)-1- cyclobutylethyl]amino}- 7-[3-fluoro-4- (trifluoromethoxy)benzyl]- 8-[5-(1-methylethyl)-2- (trifluoromethoxy)phenyl]- 7h-purine-2-carboxylic acid::US9540377, 1.83

SMILES CC(C)c1ccc(OC(F)(F)F)c(c1)-c1nc2nc(nc(N[C@H](C)C3CCC3)c2n1Cc1ccc(OC(F)(F)F)c(F)c1)C(O)=O

InChI Key InChIKey=BBORVPSOLRJJKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 213841   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 213841BDBM213841(US9540377, 1.83 | 6-{[(1r)-1- cyclobutylethyl]amin...)
Affinity DataIC50: 23.2nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent