BDBM218197 6-{[(1r)-1- cyclopropyl- ethyl]amino}- 8-(2,6-dimethyl- phenyl)-7-[4- (trifluoromethyl) benzyl]-7h- purine-2- carboxylic acid::US9540377, 2.62

SMILES Cc1cccc(C)c1-c1nc2nc(C(=O)O)nc(N[C@H](C)C3CC3)c2n1Cc1ccc(C(F)(F)F)cc1

InChI Key InChIKey=DYNITNWINGFQFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218197   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218197BDBM218197(US9540377, 2.62 | 6-{[(1r)-1- cyclopropyl- ethyl]a...)
Affinity DataIC50: 65.6nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent