BDBM218203 8-(3-chloro-4- methoxyphenyl)- 6-{[(1r)-1- cyclopropyl- ethyl]amino}- 7-[4-(trifluoro- methyl)benzyl]- 7h-purine-2- carboxylic acid::US9540377, 2.66

SMILES COc1ccc(cc1Cl)-c1nc2nc(nc(N[C@H](C)C3CC3)c2n1Cc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=RPAPAIHAPJOZAU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218203   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218203BDBM218203(US9540377, 2.66 | 8-(3-chloro-4- methoxyphenyl)- 6...)
Affinity DataIC50: 112nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent