BDBM218226 US9249087, Table 1 , Compound 3

SMILES Cc1cn(-c2ccc(cc2)C(=O)NO)c2ccccc12

InChI Key InChIKey=GHXYBEBPNZQUHN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 218226   

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50: 5.11nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Illinois

US Patent
LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50: 911nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50: 6.79E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
University of Illinois

US Patent
LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50: 1.19E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of Illinois

US Patent
LigandPNGBDBM218226(US9249087, Table 1 , Compound 3)
Affinity DataIC50: 1.45E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent