BDBM218232 BDBM50531322::US9249087, Table 1 , Compound 9

SMILES ONC(=O)c1ccc(cc1)-n1cnc2ncncc12

InChI Key InChIKey=GGIFZSQBRZDCSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 218232   

TargetHistone deacetylase 6(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM218232(BDBM50531322 | US9249087, Table 1 , Compound 9)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorescent-labelled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Indian Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM218232(BDBM50531322 | US9249087, Table 1 , Compound 9)
Affinity DataIC50: 14.2nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM218232(BDBM50531322 | US9249087, Table 1 , Compound 9)
Affinity DataIC50: 3.56E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
US Patent