BDBM218374 (r)-8-(2-(but-3-en-1-yloxy)- 5-methylphenyl)-7-(4- chlorobcnzyl)-6-((1- cyclopropylethyl)amino)- 7h-purine-2-carboxylic acid::US9540377, 4.3

SMILES C[C@@H](Nc1nc(nc2nc(-c3cc(C)ccc3OCCC=C)n(Cc3ccc(Cl)cc3)c12)C(O)=O)C1CC1

InChI Key InChIKey=LWJIQOHCKQSOSZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218374   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218374BDBM218374(US9540377, 4.3 | (r)-8-(2-(but-3-en-1-yloxy)- 5-me...)
Affinity DataIC50: 104nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent