BDBM218565 (r)-8-(2-(3-(bis(2- methoxyethyl)amino) propoxy)-5-methyl- phenyl)-7-(4- chlorobenzyl)-6-((1- cyclopropylethyl)amino)- 7h-purine-2- carboxylic acid::US9540377, 4.15

SMILES COCCN(CCCOc1ccc(C)cc1-c1nc2nc(nc(N[C@H](C)C3CC3)c2n1Cc1ccc(Cl)cc1)C(O)=O)CCOC

InChI Key InChIKey=FJXJRALJUZMHSS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 218565   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 218565BDBM218565(US9540377, 4.15 | (r)-8-(2-(3-(bis(2- methoxyethyl...)
Affinity DataIC50: 667nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent