BDBM21907 4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydroxypropyl)-6-[(1H-imidazol-4-ylmethyl)amino]quinoline-3-carbonitrile::Cyanoquinoline, 20

SMILES OCC(O)Cc1cc(NCc2cnc[nH]2)cc2c(Nc3ccc(F)c(Cl)c3)c(cnc12)C#N

InChI Key InChIKey=DOXNJPSGPQLUJS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21907   

LigandPNGBDBM21907(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50: 910nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed