BDBM220108 6-{[(1r)-1- cyclobutylethyl]amino}-7- (4-methoxybenzyl)-8-(3- methylphenyl)-7h-purine- 2-carboxylic acid::US9540377, 5.19

SMILES COc1ccc(Cn2c(nc3nc(nc(N[C@H](C)C4CCC4)c23)C(O)=O)-c2cccc(C)c2)cc1

InChI Key InChIKey=ZBSNSHYAYWFGHV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 220108   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220108BDBM220108(US9540377, 5.19 | 6-{[(1r)-1- cyclobutylethyl]amin...)
Affinity DataIC50: 582nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent