BDBM220154 3-cyclopropyl-3-({8- (3-methylphenyl)-7- [4- (trifluoromethyl)benzyl]- 7h-purin-6- yl}amino)propanoic acid::US9540377, 6.18

SMILES Cc1cccc(c1)-c1nc2ncnc(NC(CC(O)=O)C3CC3)c2n1Cc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=GWJXPUKJLGJRCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 220154   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 220154BDBM220154(US9540377, 6.18 | 3-cyclopropyl-3-({8- (3-methylph...)
Affinity DataIC50: 5.19E+3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent