BDBM22021 US8846658, 116::US8846658, 45

SMILES Cc1cc(Br)cnc1C(=O)Nc1ccc(F)c(c1)[C@@]1(COCC(N)=N1)C(F)F

InChI Key InChIKey=NSHIOKOUABVPPT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22021   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM22021(US8846658, 45 | US8846658, 116)
Affinity DataIC50: 16nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM22021(US8846658, 45 | US8846658, 116)
Affinity DataIC50: 18nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent