BDBM220804 US9296759, 72

SMILES NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(F)cn3)ccc1Oc1c(F)nc(cc21)-c1cccnc1

InChI Key InChIKey=RRKACYDXWGEQOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220804   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM220804(US9296759, 72)
Affinity DataIC50: 1.10nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM220804(US9296759, 72)
Affinity DataIC50: 3.58E+5nMpH: 3.5Assay Description:Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent