BDBM220849 US9296759, 112

SMILES COc1cnc(cn1)C(=O)Nc1ccc2Oc3c(F)nc(cc3C3(CCSC(N)=N3)c2c1)-c1cncc(F)c1

InChI Key InChIKey=PEZGSBQHDVWHLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 220849   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM220849(US9296759, 112)
Affinity DataIC50: 2.80nMpH: 4.2Assay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM220849(US9296759, 112)
Affinity DataIC50: 2.24E+5nMpH: 3.5Assay Description:Recombinant CathepsinD was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cathepsi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent