BDBM220866 US11472769, Compound BI-1467335-(PXS-4728A)::US9302986, 23
SMILES CC(C)(C)NC(=O)c1ccc(OC\C(CN)=C\F)cc1
InChI Key InChIKey=OWNSXNXYELKDSO-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 220866
Affinity DataIC50: 2nMAssay Description:Inhibition of human plasma VAP-1 using 6-(5-Pheny1-2H-tetrazol-2-yl)hexan-1-amine as substrate preincubated with enzyme for 15 mins followed by subst...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant VAP-1 using benzylamine as substrate incubated for 30 mins followed by substrate addition measured every 2.5 mins for...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of bovine plasma VAP-1 using 6-(5-Pheny1-2H-tetrazol-2-yl)hexan-1-amine as substrate preincubated with enzyme for 15 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bovine plasma VAP-1 using 6-(5-Pheny1-2H-tetrazol-2-yl)hexan-1-amine as substrate measured after 30 mins by UV-HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human MAO-B using 4-(5-phenyl-2H-tetrazol-2-yl)butan-1-amine as substrate preincubated with enzyme for 15 mins followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of porcine kidney DAO using 6-(5-phenyltetrazol-2-yl)hexan-1-amine as substrate preincubated with enzyme for 15 mins followed by substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Amine oxidase activity of recombinant hSSAO, hMAO-A, and hMAO-B isoforms are measured using the MAO-Glo assay kit (Promega, V1402). Ten nL test compo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:Abdominal fat from BALB/c mice, Wistar or Sprague Dawley rats, which are tissues enriched with SSAO/VAP-1-were surgically removed. For every gram of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.4Assay Description:Briefly, HMEC cell expressing human SSAO/VAP-1 were grown in several 10 cm petri dishes, once the cells reached 100% confluency, cells were harvested...More data for this Ligand-Target Pair