BDBM221237 8-(3-methylphenyl)-7- [4- (trifluoromethyl)benzy]- 6-[(1,2,2- trimethylpropyl)amino]- 7h-purine-2- carboxylic acid::US9540377, 6.74

SMILES CC(Nc1nc(nc2nc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C(C)(C)C

InChI Key InChIKey=RTAIJZFVCRNVRQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221237   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 221237BDBM221237(US9540377, 6.74 | 8-(3-methylphenyl)-7- [4- (trifl...)
Affinity DataIC50: 553nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent