BDBM221249 US9303015, 23

SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1

InChI Key InChIKey=FEMFLJUOZBWZNG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 221249   

TargetNuclear receptor ROR-gamma [258-518](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221249(US9303015, 23)
Affinity DataKd:  26nMpH: 7.0 T: 2°CAssay Description:ThermoFluor® experiments were carried out using instruments owned by Janssen Research and Discovery, L.L.C. through its acquisition of 3-Dimensio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221249(US9303015, 23)
Affinity DataIC50: 700nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221249(US9303015, 23)
Affinity DataIC50: 1.20E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [258-518,Y502F](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM221249(US9303015, 23)
Affinity DataIC50: 2.00E+3nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2017
Entry Details
US Patent