BDBM22219 1,2,4-oxadiazole based compound, 36::1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]methyl}azetidine-3-carboxylic acid

SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)[C@H]2CCC(F)(F)C2)C1

InChI Key InChIKey=QIPIWIXFCSCVEI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22219   

TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

LigandPNGBDBM22219(1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2008
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Research Laboratories

LigandPNGBDBM22219(1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2008
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

LigandPNGBDBM22219(1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 68nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2008
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

LigandPNGBDBM22219(1-{[4-(5-{4-[(1S)-3,3-difluorocyclopentyl]phenyl}-...)
Affinity DataIC50: 4.28E+3nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2008
Entry Details Article
PubMed