BDBM223358 US9315520, Comparator 7::US9605007, Comparator 7::US9744173, Comparator 7

SMILES [H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=UOHXUSCZQJMWQO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 223358   

TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 1nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 1nMAssay Description:The BACE1 and BACE2 binding assays measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 1nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Pfizer

US Patent
LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 30nMAssay Description:CYP2D6 inhibition was obtained by measuring inhibition of 5 uM Dextromethorphan in pooled HLM (HL-MIX-102).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 200nMT: 2°CAssay Description:All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

LigandPNGBDBM223358(US9315520, Comparator 7 | US9605007, Comparator 7 ...)
Affinity DataIC50: 200nMAssay Description:All testing was carried out in CHO cells transfected with the hERG gene purchased from Millipore (PrecisION hERG-CHO Recombinant Cell Line CYL3038). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent