BDBM223407 US9315520, 1-HCl

SMILES C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1

InChI Key InChIKey=ZLZUHACSRMOLLV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223407   

TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Human)
Pfizer

US Patent
LigandPNGBDBM223407(US9315520, 1-HCl)
Affinity DataIC50: 31nMpH: 4.5 T: 2°CAssay Description:The substrate is Biotin-GLTNIKTEEISEISY^EVEFR-C[Oregon Green]KK-OH. The BACE1 enzyme is affinity purified material from conditioned media of CHO-K1 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent