BDBM223595 6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-8-(2-pyridin- 2-ylpiperidin-1-yl)- 7h-purine-2- carboxylic acid::US9540377, 11.21

SMILES C[C@@H](Nc1nc(C(=O)O)nc2nc(N3CCCCC3c3ccccn3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=DMLDTQPTYLJEEZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223595   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223595BDBM223595(US9540377, 11.21 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 2.72nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent