BDBM223673 3-{8-[3-(4- chlorophenyl)morph- olin-4-yl]-6-{[(1r)- 1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl}-1,2,4-oxadiazol- 5(4h)-one::US9540377, 11.119::US9540377, 11.99

SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(N3CCOCC3c3ccc(Cl)cc3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=CEUPRVKOJHAQPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 223673   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223673BDBM223673(US9540377, 11.99 | US9540377, 11.119 | 3-{8-[3-(4-...)
Affinity DataIC50: 3.43nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223673BDBM223673(US9540377, 11.99 | US9540377, 11.119 | 3-{8-[3-(4-...)
Affinity DataIC50: 24.8nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent