BDBM223728 5-(6-{[(1r)-1- cyclobutylethyl]amino}- 8-[(cis)-2,3- dimethylmorpholin- 4-yl]-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl)-1,3,4-oxadiazol- 2(3h)-one (diastereomer 1)::US9540377, 11.157::US9540377, 11.158::US9540377, 11.167
SMILES CC1OCCN(c2nc3nc(-c4n[nH]c(=O)o4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)C1C
InChI Key InChIKey=PHWMILWUUXEUGX-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 223728
Affinity DataIC50: 2.16nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Affinity DataIC50: 12.9nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Affinity DataIC50: 47.0nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair