BDBM223734 3-(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-8-[(2s,3r)-2- methyl-3- phenylmorpholin-4- yl]-7h-purin-2-yl)- 1,2,4-oxadiazol- 5(4h)-one::US9540377, 11.163

SMILES C[C@@H]1OCCN(c2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)[C@@H]1c1ccccc1

InChI Key InChIKey=ONZOHYSBOCAUJY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223734   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223734BDBM223734(US9540377, 11.163 | 3-(6-{[(1r)-1- cyclobutylethyl...)
Affinity DataIC50: 21.2nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent