BDBM223741 US9540377, 12.3::n-[(1r)-1-cyclobutylethyl]- 8-[4-(propan-2-yl)pyridin- 2-yl]-2-(1h-1,2,3-triazol-5- yl)-7-[4- (trifluoromethyl)benzyl]- 7h-purin-6-amine

SMILES CC(C)c1ccnc(-c2nc3nc(-c4cnn[nH]4)nc(N[C@H](C)C4CCC4)c3n2Cc2ccc(C(F)(F)F)cc2)c1

InChI Key InChIKey=QAFZSXXBWUTEHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223741   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223741BDBM223741(US9540377, 12.3 | n-[(1r)-1-cyclobutylethyl]- 8-[4...)
Affinity DataIC50: 535nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent